Therapeutic efficacy of intraperitoneally injected curcumin on experimentally induced hamster buccal pouch carcinoma

Abstract: The aim of the present study was directed to investigate therapeutic efficacy intraperitoneally injected curcumin as anticarcinogenic treatment modality on 7,12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch(s) (HBP(s)) carcinoma. Subjects and methods: Thirty Syrian male hamsters, five weeks old, weighing 90-130g were divided into three group(s) (G(s)): A, B, C. G-A (negative control): HBP mucosa 10 animals painted with liquid paraffin alone times a week for 14 weeks. G-B (positive 0.5% DMBA in oil 3 Then left untreated 6 after painting. G-C (curcumin treated group): 80 mg/kg body weight every day following DMBA-treatment. assessment based gross observation, histological immunohistochemical examination utilizing anti-apoptotic Bcl-2 antibody. Results: Gross observation revealed variation reduction tumor size group (G-C) compared that observed G-B. Histopathological findings variations between groups. Immunohistochemical results expression has variability area % throughout groups used. Groups G-A, G-B, 7.78%, 75.51%, 41.65% respectively. Conclusion: effect resulted promising outcome regression